HQ Team
August 12, 2025: Researchers from Jiangnan University in China have discovered a potential natural alternative to Ozempic, a popular GLP-1 receptor agonist used as a weight loss drug.
This natural approach involves leveraging gut microbes and their metabolites to regulate blood sugar levels and suppress sugar cravings, offering hope for those seeking a non-pharmaceutical option for weight management.
Ozempic, whose active ingredient is semaglutide, works by mimicking the body’s natural GLP-1 hormone. GLP-1 helps regulate blood sugar and appetite, making Ozempic effective for weight loss and diabetes management. However, some individuals may experience side effects such as nausea and constipation. Additionally, the cost and accessibility of Ozempic have prompted researchers to explore natural alternatives.
Gut microbe and GLP-1
The study revealed that a gut microbe called Bacteroides vulgatus and its metabolites can promote the secretion of GLP-1. By increasing the abundance of this gut microbe in diabetic mice, researchers observed enhanced secretion of GLP-1 and FGF21, leading to better blood sugar control and reduced sugar cravings. This mechanism is similar to the effects of Ozempic but is achieved through natural means.
 Stanford Medicine researchers discovered a natural molecule called BRP, which acts through a metabolic pathway similar to Ozempic’s. BRP activates different neurons in the brain, offering a more targeted approach to weight reduction. In animal studies, BRP was found to suppress appetite and reduce body weight without some of Ozempic’s side effects.
Natural GLP-1 supplements, such as those containing berberine and green tea extract, are also gaining attention. While their effects may not match those of Ozempic, they may offer mild weight loss benefits and are more accessible to some individuals.
“A growing body of research has revealed that our cravings for dietary components originate from signals sent from the gut, a key organ in transmitting dietary preferences,” explain the authors in their paper published in January.
“However, which genes, gut flora, and metabolites in the gut microenvironment are involved in the regulation of sugar preference is currently unclear.”
These findings suggest that gut microbes and natural molecules could serve as potential alternatives to Ozempic, providing new avenues for weight loss and metabolic health management. However, further research is needed to confirm their effectiveness and safety in humans.
If you are interested in exploring natural alternatives to Ozempic, consult with a healthcare professional to determine the best approach for your specific needs.
